DESCRIPTION: Mephloquine is obtained in five steps, where reactions with organometallics and catalytic hydrogenation under pressure are involved.
MAIN ADVANTAGES: Domestic production of the most potent synthetic antimalarial known at present.
MAIN APPLICATIONS: Pharmaceutical product with antimalarial activity.
STAGE OF DEVELOPMENT: Developed on laboratory scale. Still in optimization phase.
PERSONS IN CHARGE: Nubia Boechat, Benjamin Gilbert and Andr Gemal
UNIT/DEPARTMENT/DIVISION: Instituto de Tecnologia em Farmacos de Manguinhos-FARMANGUINHOS / Department of Research and Technological Development